With a myriad of overlapping hormones and neurotransmitters involved, weight regulation is a complex task. While our bodies aim to stow away energy reserves for emergent times, our patients simultaneously try desperately to shed unwanted pounds. As Sandra Aamodt, PhD, author and former editor-in-chief of Nature Neuroscience, tells host Dr. Leslie Lundt, thanks to leptin, and a host of other regulatory compounds, many patients face long odds making a permanent change in food intake.